Chronic Granulomatous Disease on Jeju Island, Korea
نویسندگان
چکیده
chia coli, non-typhoid Salmonella species, Klebsiella pneumoniae, Serratia marcescens, and Burkholderia cepacia, as well as the fungal genus Aspergillus. 3-6) Isolation of the causative pathogens is essential for appropriate antimicrobial therapy, but it is difficult to identify the causative pathogen in most clinical CGD cases. 6) NADPH oxidase is a multi-component complex composed of a plasma membrane-bound flavocytochrome b558 subunit and cytosolic proteins p47 (phox for phagocytic oxidase), p67, p40, and two small GTPase, Rac2 and Rap1A. The flavocytochrome b558 subunit is a heterodimer comprised of gp91 phox (also called NOX2, NOX for NADPH oxidase) and p22 encoded by CYBB and CYBA respectively, whereas the three components p47, p67, and p40 of the cytosolic subunit are encoded Chronic Granulomatous Disease on Jeju Island, Korea
منابع مشابه
Genetic Analysis of 10 Unrelated Korean Families with p22-phox-deficient Chronic Granulomatous Disease: An Unusually Identical Mutation of the CYBA Gene on Jeju Island, Korea
Chronic granulomatous disease (CGD) is a rare hereditary disorder characterized by recurrent life-threatening bacterial and fungal infections. The underlying defect in CGD is an inability of phagocytes to produce reactive oxygen species as a result of defects in NADPH oxidase. Considering that CGD generally affects about 3-4 in 1,000,000 individuals, it is surprising that the prevalence of CGD ...
متن کاملLong-term outcome of patients with p22phox-deficient chronic granulomatous disease on Jeju Island, Korea
PURPOSE This study investigated the long-term clinical outcomes of patients with p22 (phox) -deficient chronic granulomatous disease (CGD) on Jeju Island and retrospectively evaluated the effects of interferon-gamma (IFN-γ) prophylaxis. METHODS The medical records of 15 patients with CGD were retrospectively reviewed. The efficacy of IFN-γ prophylaxis was evaluated by comparing the frequency ...
متن کامل1481Foodborne Outbreak of Human Brucellosis Caused by Ingested Raw Fetal Material of Cattles on Jeju Island
Fetal Material of Cattles on Jeju Island Seung Jin Yoo; Sang Taek Heo MD, PhD; Jeong Rae Yoo,; Keun Hwa Lee; Jeju National University School of Medicine, Jeju Special-Governing Province, South Korea; Internal Medicine, Jeju National University School of Medicine, Jeju SpecialGoverning Province, South Korea; Department of Microbiology and Immunology, Jeju National University School of Medicine, ...
متن کاملEpidemiologic characteristics of scrub typhus on Jeju Island
OBJECTIVES Scrub typhus is the most common febrile disease in Korea during the autumn. Jeju Island is the largest island in South Korea and has a distinctive oceanic climate. This study aimed to identify epidemiologic characteristics of scrub typhus on Jeju Island. METHODS From January 2011 to December 2016, 446 patients were diagnosed with scrub typhus on Jeju Island. The patients' personal ...
متن کاملThe Effects of Climate Change and Globalization on Mosquito Vectors: Evidence from Jeju Island, South Korea on the Potential for Asian Tiger Mosquito (Aedes albopictus) Influxes and Survival from Vietnam Rather Than Japan
BACKGROUND Climate change affects the survival and transmission of arthropod vectors as well as the development rates of vector-borne pathogens. Increased international travel is also an important factor in the spread of vector-borne diseases (VBDs) such as dengue, West Nile, yellow fever, chikungunya, and malaria. Dengue is the most important vector-borne viral disease. An estimated 2.5 billio...
متن کامل